Metabolic Related Deficits in Brain Tissues from Patients with Parkinsonism Resemble Those from Pesticide Exposed Animals

•In MSA patients, gene expression deficits occurred in mitochondrial complexes I, III, and IV •Similarly, animal studies involving exposure to, for example, rotenone, paraquat, diquat, pyridaben, fenpyroximate, fenazaquin, and/or tebunfenpyrad defined alterations in function in mitochondrial complexes specific for the different pesticides.